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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Biochim Biophys Acta Biomembr. 2019 Jul 8;1862(1):183016. doi: 10.1016/j.bbamem.2019.07.004

Figure 1. Intramembrane proteolysis of Notch and APP by γ-secretase.

Figure 1.

The γ-secretase complex cuts the single TMD of Notch substrate to release the Notch intracellular domain (NICD), which translocates to the nucleus and regulates gene expression. A short Notch-β (Nβ) peptide is also released. The protease cuts the single TMD of APP substrate to produce the amyloid-β peptide (Aβ) and APP intracellular domain (AICD). The identification of C-termini of Nβ and Aβ peptides and N-termini of the respective intracellular domains reveals that these substrates are cleaved at least twice by γ-secretase.