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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Res Microbiol. 2019 Aug 1;170(8):374–380. doi: 10.1016/j.resmic.2019.07.003

Fig. 3.

Fig. 3.

Model for the activation of amidases by FtsEX. EnvC binds to the large extracellular loop of FtsX independent of ATP. This binding occurs through the coiled coil domain of EnvC. Note, the stoichiometry between FtsX and EnvC is not known, but is drawn here as 1:1. As sPG is synthesized amidases are recruited and activated by ATP hydrolysis of FtsEX. ATP binding leads to conformational changes in FtsEX which impact EnvC leading to activation of AmiB (and AmiA). These amidases are autoinhibited and this must be reversed by the conformational changes in FtsX which are transmitted to EnvC. ATP hydrolysis by FtsEX resets the system.