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. Author manuscript; available in PMC: 2020 Jun 2.
Published in final edited form as: Nat Struct Mol Biol. 2019 Dec 2;26(12):1167–1175. doi: 10.1038/s41594-019-0344-5

Figure 1. The Env protomers in E51-sCD4-BG505 complexes adopt two distinct conformations.

Figure 1.

a, Cryo-EM density maps of class I and class II E51-sCD4-BG505 structures. b, Cartoon representations of Envs from the two structural classes. Inset shows a topology diagram for the four-stranded bridging sheet and the exposed V3 loop (mostly disordered) that comprise part of the E51 epitope on gp120. c, Surface representations comparing CD4i Fabs (E51, 17b, and 21c) bound to the gp120-sCD4 portions of CD4i-sCD4-Env trimer complex structures (PDBs 6CM3 and 6EDU for the 17b and 21c complex structures, respectively).