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. Author manuscript; available in PMC: 2020 Jun 2.
Published in final edited form as: Nat Struct Mol Biol. 2019 Dec 2;26(12):1167–1175. doi: 10.1038/s41594-019-0344-5

Extended Data Fig. 5. Comparison of fusion peptide conformations in Env structures.

Extended Data Fig. 5

The fusion peptide is orange in the conformation A protomer, cyan in the conformation B protomer (from the E51-sCD4-BG505 complex structures reported here), teal in a partially-open 17b-sCD4-BG505–8ANC195 complex (PDB 6CM3), and pale cyan in a fully-open 17b-sCD4-B41 complex (PDB 5VN3). Fusion peptides from Env trimers in a closed, prefusion conformation are color coded as shown for their PDB IDs. References for structures are listed in Supplementary Table 2.