Figure 1. Induction of Type 1 diabetes with streptozotocin (STZ) in WT and IL-10 knockout mice.
C57BL/6 (WT) and IL-10 knockout (KO) mice were treated with citrate buffer (vehicle control) or STZ (diabetic) for 5 consecutives days. (A) Blood glucose levels (mg/dL) and (B) body weight in grams (g) were measured 4 weeks after the first STZ injection. Whiskers in the box plot represent 5–95 percentile values; n= 9–10 per group. *p<0.05, ****p<0.0001. Statistical analysis performed by One-way ANOVA followed by Fisher’s LSD post-test. WT=wild type, KO= IL-10 knockout mice.