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. Author manuscript; available in PMC: 2021 Mar 1.

Published in final edited form as: J Cell Physiol. 2019 Sep 19;235(3):2350–2365. doi: 10.1002/jcp.29141

Figure 2. — Control and STZ treated WT and IL-10 knockout mice were euthanized 4 weeks after the first STZ injection. Femoral bones were collected and trabecular bone analyzed by uCT. (A) Representative micro-computed tomography isosurface images. (B) Bone volume fraction (corrected for weight loss). (C) Bone volume fraction (corrected for weight loss) from the KO group normalized to respective WT groups. * represent p<0.05 by T-test against WT diabetic group. (D) Bone mineral content (mg). (E) Bone mineral density (mg/cc). (F) Trabecular number (Tb. N, 1/mm). (G) Trabecular space (Tb. Sp, mm). (H) Trabecular thickness (Tb. Th, um). Bar graphs values are averages ± standard error; Whiskers in box plots represent 5–95 percentile values; n= 7–9 per group. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. Statistical analysis performed by One-way ANOVA followed by Fisher’s LSD post-test. WT=wild type, KO= IL-10 knockout mice.

Figure 2. — Control and STZ treated WT and IL-10 knockout mice were euthanized 4 weeks after the first STZ injection. Femoral bones were collected and trabecular bone analyzed by uCT. (A) Representative micro-computed tomography isosurface images. (B) Bone volume fraction (corrected for weight loss). (C) Bone volume fraction (corrected for weight loss) from the KO group normalized to respective WT groups. * represent p<0.05 by T-test against WT diabetic group. (D) Bone mineral content (mg). (E) Bone mineral density (mg/cc). (F) Trabecular number (Tb. N, 1/mm). (G) Trabecular space (Tb. Sp, mm). (H) Trabecular thickness (Tb. Th, um). Bar graphs values are averages ± standard error; Whiskers in box plots represent 5–95 percentile values; n= 7–9 per group. *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001. Statistical analysis performed by One-way ANOVA followed by Fisher’s LSD post-test. WT=wild type, KO= IL-10 knockout mice.