Figure 4. IL-10 knockout exacerbates vertebral trabecular bone loss 1 month after diabetes induction.

Vertebral bones were collected from mice groups described in Fig 2 and μCT analysis performed from the third lumbar vertebral body to assess trabecular bone. (A) Representative micro-computed tomography isosurface images. (B) Percent bone volume fraction and (C) bone volume fraction from the KO groups normalized to respective WT groups. * represent p<0.05 by T-test against WT diabetic group. Bar graphs values are averages ± standard error; n= 5–7 per group. *p<0.05, **p<0.01. Statistical analysis performed by One-way ANOVA followed by Fisher’s LSD post-test. WT=wild type, KO=IL-10 knockout mice.