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. Author manuscript; available in PMC: 2021 Mar 1.

Published in final edited form as: J Cell Physiol. 2019 Sep 19;235(3):2350–2365. doi: 10.1002/jcp.29141

Figure 5. — Control and STZ treated WT and IL-10 knockout mice were euthanized 12 weeks after the first STZ injection. Femoral bones were collected and trabecular bone analyzed by uCT. (A) Blood glucose levels (mg/dL) and (B) body weight in grams (g); n=9–10. (C) Representative micro-computed tomography isosurface images. (D) Bone volume fraction (corrected for weight loss). (E) Bone volume fraction (corrected for weight loss) from the KO group normalized to respective WT groups. (F) Bone mineral content (mg). (G) Bone mineral density (mg/cc). (H) Trabecular number (Tb.N, 1/mm). (I) Trabecular space (Tb.Sp, mm). (J) Trabecular thickness (Tb.Th, um). Bar graphs values are averages ± standard error; Whiskers in box plots represent 5–95 percentile values; n= 5–9 per group. **p<0.01, ****p<0.0001. Statistical analysis performed by One-way ANOVA followed by Fisher’s LSD post-test. WT=wild type, KO=IL-10 knockout mice.

Figure 5. — Control and STZ treated WT and IL-10 knockout mice were euthanized 12 weeks after the first STZ injection. Femoral bones were collected and trabecular bone analyzed by uCT. (A) Blood glucose levels (mg/dL) and (B) body weight in grams (g); n=9–10. (C) Representative micro-computed tomography isosurface images. (D) Bone volume fraction (corrected for weight loss). (E) Bone volume fraction (corrected for weight loss) from the KO group normalized to respective WT groups. (F) Bone mineral content (mg). (G) Bone mineral density (mg/cc). (H) Trabecular number (Tb.N, 1/mm). (I) Trabecular space (Tb.Sp, mm). (J) Trabecular thickness (Tb.Th, um). Bar graphs values are averages ± standard error; Whiskers in box plots represent 5–95 percentile values; n= 5–9 per group. **p<0.01, ****p<0.0001. Statistical analysis performed by One-way ANOVA followed by Fisher’s LSD post-test. WT=wild type, KO=IL-10 knockout mice.

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