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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Biochim Biophys Acta Biomembr. 2019 Sep 5;1862(1):183058. doi: 10.1016/j.bbamem.2019.183058

Figure 3. Segmental Intolerance Analysis of APH-1, Nicastrin and PEN-2.

Figure 3.

MTR plots for (A) APH-1, (B) Nicastrin (NCSTN), and (C) PEN-2. The transmembrane (TM) domains of APH-1, NCSTN, and PEN-2 are shown below their respective MTR plots. (D) The intolerant regions of nicastrin (NCSTN) and APH-1 are mapped onto the structure (PDB: 6IYC) using red surfaces.