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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Biochim Biophys Acta Biomembr. 2019 Sep 5;1862(1):183058. doi: 10.1016/j.bbamem.2019.183058

Figure 4. Segmental Intolerance Analysis of the Amyloid Precursor Protein (APP).

Figure 4.

MTR plot for human APP. A lollipop plot showing locations of the familial Alzheimer’s disease mutations superimposed on the domain organization of APP are shown on top of the MTR plot. SP – signal peptide, GFLD – growth factor-like domain, CuBD – copper-binding domain, KPI - Kunitz-type protease inhibitor, TM – transmembrane domain.