Central illustration. The Phenotypes of HFpEF:
There are key clinical phenotypes that demonstrate distinct pathophysiologic features compared to “garden variety of HFpEF”. FA, fatty acid; fxn, function; HFpEF, heart failure with preserved ejection fraction; HR, heart rate; LA, left atrial; LV, left ventricular; NO-cGMP, nitric oxide-cyclic guanosine monophosphate signaling; O2, oxygen; PA, pulmonary artery; PH, pulmonary hypertension; PV, pulmonary vascular; and RV, right ventricular.