Table 2.
Relative organ weight of Sprague-Dawley rats following the 90-day oral pretreatment with vehicle (Tween 80) or MEMM in the subchronic toxicity study.
| Organs | Male | |||
|---|---|---|---|---|
| Control | Treatment | |||
| Tween 80 | MEMM (mg/kg) | |||
| — | 50 | 250 | 500 | |
| Spleen | 0.21 ± 0.04 | 0.17 ± 0.01 | 0.20 ± 0.02 | 0.16 ± 0.01 |
| Liver | 2.76 ± 0.35 | 3.76 ± 0.07 | 2.93 ± 0.25 | 2.71 ± 0.12 |
| Heart | 0.35 ± 0.03 | 0.33 ± 0.01 | 0.34 ± 0.02 | 0.29 ± 0.02 |
| Kidney | 0.74 ± 0.06 | 0.64 ± 0.02 | 0.72 ± 0.03 | 0.61 ± 0.01 |
| Lung | 0.78 ± 0.07 | 0.71 ± 0.04 | 0.95 ± 0.13 | 0.90 ± 0.11 |
| Colon | 0.84 ± 0.13 | 0.77 ± 0.07 | 0.81 ± 0.07 | 0.70 ± 0.03 |
Values are expressed as means ± SEM. Groups (n = 6): control (treated with Tween 80); treatments (treated with 50 mg/kg MEMM, 250 mg/kg MEMM, and 1000 mg/kg MEMM).