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. 2019 Nov 26;2019:2503924. doi: 10.1155/2019/2503924

Figure 5.

Figure 5

HIF-1α promoter methylation patterns in CD8+ T cells from vitiligo patients, 5-azaC-treated CD8+ T cells, and normal controls. (a) Methylation status of 2 CG pairs (positions HIF-1α-8-40 and HIF-1α-8-133) was decreased in vitiligo patients compared to these positions of normal control (p < 0.05 and p < 0.01, respectively) (n = 6). (b) Methylation status of 3 CG pairs (positions HIF-1α-7-165, HIF-1α-7-172, and HIF-1α-8-40) was reduced in 5-azaC-treated CD8+ T cells compared to normal CD8+ T cells (p < 0.05, p < 0.05, and p < 0.01, respectively) (n = 6). (c, d) The mRNA and protein expression level of HIF-1α (p < 0.05 and p < 0.05, respectively) was increased in 5-azaC-treated CD8+ T cells compared to normal CD8+ T cells (n = 8 and n = 3, respectively). Data are shown as mean ± SEM. ∗p < 0.05; ∗∗p < 0.01.