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. 2019 Apr 15;41(6):556–567. doi: 10.1590/1516-4446-2018-0116

Table 4. GRADE evidence profile according to WHOQOL-Bref domains of the studies included in meta-analysis.

Factors which would downgrade the quality of evidence Factors which would upgrade the quality of evidence Summary of results
WHOQOL-Bref outcomes (n) Limitations Inconsistency Indirectness Imprecision Publication bias Large effect Dose-response Confounders Other Quality of evidence/response Comments
Physical domain
7 studies (3,402)
Undetected (0) Detected
I2 = 51.42 (-1)
Undetected (0) Undetected
Power of meta-analysis ≥ 80% (0)
Undetected (0) N/A (0) N/A (0) Confounder increased confidence in estimated effects in all studies (+1) Detected representative samples (+1) Moderate +1 due to sample characteristics
Psychological domain
7 studies (3,402)
Undetected (0) Detected
I2 = 20.83 (0)
Undetected (0) Undetected
Power of meta-analysis ≥ 80% (0)
Undetected (0) N/A (0) N/A (0) Confounder increased confidence in estimated effects in all studies (+1) Detected representative samples (+1) High +1 due to sample characteristics
Social relationship domain
7 studies (3,402)
Undetected (0) Detected
I2 = 51.38 (-1)
Undetected (0) Detected
Power of meta-analysis = 15.36% (-2)
Undetected (0) N/A (0) N/A (0) Confounder increased confidence in estimated effects in all studies (+1) Detected representative samples (+1) Low +1 due to sample characteristics
Environment domain
7 studies (3,402)
Undetected (0) Undetected
I2 = 0.0 (0)
Undetected (0) Detected
Power of meta-analysis = 45% (-2)
Undetected (0) N/A (0) N/A (0) Confounder increased confidence in estimated effects in all studies (+1) Detected representative samples (+1) Low +1 due to sample characteristics

N/A = not applicable or not rated.