REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
LEAF-purified mouse anti-human CD3 (clone UCHT1)	Biolegend	Discontinued Alternative: Cat# 300438; RRID: AB_11146991
LEAF-purified mouse anti-human CD28 (clone CD28.2)	Biolegend	Cat# 302914; RRID: AB_314316
LEAF-purified mouse anti mouse/rat/human MR1 (clone 26.5)	Biolegend	Cat# 361103; RRID: AB_2563041
Anti-human CD3 (clone UCHT1) PerCp/Cy.5	Biolegend	Cat# 300428; RRID: AB_893298
Anti-human CD3 (clone OKT3) eFluor450	eBioScience	Cat# 48-0037-42; RRID: AB_1272055
Anti-human CD3 (clone OKT3) BV605	Biolegend	Cat# 317321; RRID: AB_11126166
Anti-human CD4 (clone M-T466) VioGreen	Miltenyi	Cat# 130-113-259; RRID: AB_2726060
Anti-human CD4 (clone OKT4) PerCP/Cy5.5	eBioScience	Cat# 45-0048-42; RRID: AB_10804390
Anti-human CD8 (clone SK1) FITC	Biolegend	Cat# 344704; RRID: AB_1877178
Anti-human CD8 (clone REA734) VioGreen	Miltenyi	Cat# 130-110-684; RRID: AB_2659245
Anti-human CD8 (clone REA734) PE-Vio770	Miltenyi	Cat# 130-110-680; RRID: AB_2659245
Anti-human CD39 (clone A1) PE	Biolegend	Cat# 328207; RRID: AB_940427
Anti-human CD69 (clone H1.2F3) eFluor450	eBioScience	Cat# 48-0691-82; RRID: AB_10719430
Anti-human CD103 (Ber-ACT8) PE	Biolegend	Cat# 350206; RRID: AB_10641843
Anti-human CD161 (clone 191B8) APC	Miltenyi	Cat# 130-113-590; RRID: AB_2733346
Anti-human CD161 (clone 191B8) PE	Miltenyi	Cat# 130-113-593; RRID: AB_2733772
Anti-human CD161 (clone 191B8) PE-Vio770	Miltenyi	Cat# 130-113-594; RRID: AB_2751134
Anti-human CCL3/(4) (clone 93342) APC	R&D Systems	Cat# AF270NA; RRID: AB_354436
Anti-human Furin (clone 222722) AF647	R&D Systems	Cat# IC1503R-100UG; https://www.rndsystems.com/products/human-furin-alexa-fluor-647-conjugated-antibody-222722_ic1503r
Anti-human GM-CSF (clone BVD2-21C11) PerCP/Cy5.5	Biolegend	Cat# 502312; RRID: AB_11147946
Anti-human GrB (clone GB12) APC	Initrogen	Cat# MHGB05; RRID: AB_1500190
Anti-human GrB (clone GB11) AF700	BD BioSciences	Cat# 561016; RRID: AB_2033973
Anti-human IFNγ (clone 4S.B3) AF700	Biolegend	Cat# 502520; RRID: AB_528921
Anti-human IFNγ (clone 45-15) FITC	Miltenyi	Cat# 130-091-641; RRID: AB_244194
Anti-human IFNγ (clone 4S.B3) PE/Cy7	Biolegend	Cat# 502528; RRID: AB_2123323
Anti-human IgG2bκ (clone 133303) AF647	R&D Systems	Cat# IC0041R; RRID: AB_2737095
Anti-human PD-1 (clone EH12.2H7) BV421	Biolegend	Cat# 329920; RRID: AB_10960742
Anti-human/mouse PLZF (clone R17-809) PE	BD Pharmigen	Cat# 564850; RRID: AB_2738984
Anti-human TNFα (clone Mab11) FITC	Biolegend	Cat# 502906; RRID: AB_315258
Anti-human TNFα (clone Mab11) PerCP/Cy5.5	Biolegend	Cat# 502926; RRID: AB_2204081
Anti-human Vα7.2 (clone 3C10) APC	Biolegend	Cat# 351708; RRID: AB_10933246
Anti-human Vα7.2 (clone 3C10) FITC	Biolegend	Cat# 351704; RRID: AB_10900975
Anti-human Vα7.2 (clone 3C10) PE	Biolegend	Cat# 351710; RRID: AB_2561954
Anti-human Vα7.2 (clone 3C10) PE/Cy7	Biolegend	Cat# 31712; RRID: AB_2561994
Anti-human TCRγ/δ (clone IMMU510) FITC	Beckman Coulter	Cat# IM1571U; https://www.mybeckman.uk/reagents/coulter-flow-cytometry/antibodies-and-kits/single-color-antibodies/tcr-pan-g-d/im1571u
Anti-human TCRγ/δ (clone 11F2) APC-Vio770	Miltenyi	Cat# 130-113-501; RRID: AB_2751120
Bacterial and Virus Strains
E.coli DH5α	Invitrogen	Cat# 18265017
Biological Samples
Leukocyte cones	NHS Blood and Transplant	https://www.nhsbt.nhs.uk/
Patient-derived resections (CRC)	TGU Biobank	https://www.expmedndm.ox.ac.uk/tgu/tgu-biobank-ibd-cohort
Patient-derived resection (IBD)	TGU Biobank	https://www.expmedndm.ox.ac.uk/tgu/tgu-biobank-ibd-cohort
Chemicals, Peptides, and Recombinant Proteins
Brefeldin A solution (1000X)	eBioScience	Cat# 00-4506-51
5-OP-RU	Fairlie group, Mak et al., 2017	N/A
Collagenase A	Roche (mft)/ Merck	Cat# 10103578001
DNase I	Roche (mft)/ Merck	Cat# 11284932001
SuperScript III Reverse Transcriptase	Invitrogen	Cat# 18080093
Human IL-12, premium grade	Miltenyi	Cat# 130-096-705
Human IL-15, premium grade	Miltenyi	Cat# 130-095-764
Recombinant Human IL-18	MBL	Cat# B001-5
Recombinant Human TL1A/TNFSF15	R&D Systems	Cat# 1319-TL-010
Critical Commercial Assays
T cell Activation/Expansion Kit, human	Miltenyi	Cat# 130-091-441
RNeasy Micro Kit	Quiagen	Cat# 74004
LIVE/DEAD Fixable Near IR Dead Cell Stain Kit	Invitrogen	Cat# L10119
Permeabilization buffer (10x)	eBioScience	Cat# 00-8333-56
CD8 MicroBeads, human	Miltenyi	Cat# 130-045-201
Deposited Data
RNA-seq files (UT, T, C, CT)	This Paper	GEO GSE129906
Experimental Models: Cell Lines
THP-1	ATCC	TIB-202; RRID: CVCL 0006
Caco2	ATCC	HTB-37; RRID: CVCL 0025
Oligonucleotides
Primer specific for OSM: Forward > cttccccagtgag gagacc	Roche	N/A
Primer specific for OSM: Reverse > ctgctctaagtcg gccagtc	Roche	N/A
Primer specific for HBEGF: Forward > tggggcttctc atgtttagg	Roche	N/A
Primer specific for HBEGF: Reverse > catgcccaac ttcactttctc	Roche	N/A
Primer specific for GAPDH: Forward > ccccggtttc tataaattgagc	Roche	N/A
Primer specific for GAPDH: Reverse > cttccccatgg tgtctgag	Roche	N/A
Software and Algorithms
Bioinformatics & Evolutionary Genomics	Ghent University	http://bioinformatics.psb.ugent.be/webtools/Venn/
FlowJo 10	Tree Star	https://www.flowjo.com
GSEA version 3.0	Subramanian et al., 2005	https://software.broadinstitute.org/gsea/index.jsp
Heatmapper	Wishart group, University of Alberta	http://www.heatmapper.ca
ImageJ Version 1.8	NIH	https://imagej.nih.gov/ij/index.html
Partek Flow	Partek	http://www.partek.com/partek-flow/
Prism Version 6.0b	Graphpad	https://www.graphpad.com
ZellExplorer	Zellkraftwerk GmbH	http://www.zellkraftwerk.com/products/
Other
5-OP-RU-MR1-Tetramer PE	NIH tetramer core facility	N/A
PerColl	GE Healthcare (mft)/ Merck	Cat# GE17-0891-01
Human IL26 TaqMan Probe	Thermo Fisher Scientific	Hs00218189_m1
TaqMan Fast Advanced Master Mix	Thermo Fisher Scientific	Cat# 4444557
Zellsafe Tissue chips	Zellkraftwerk GmbH	no. 28050606/02-010