Table 1.
Characteristics of the study populations in ALSPAC and MAAS cohorts
| Characteristics | Study sampled | Excluded sample (no data on outcome and/or genetics) | P‐valuec | ||
|---|---|---|---|---|---|
| N with characteristic (%) | Total N | N with characteristic (%) | Total N | ||
| ALSPAC | |||||
| Gender (male) | 3244 (51.1) | 6345 | 4375 (51.6) | 8479 | 0.575 |
| Lower combined social classa | 2617 (43.9) | 5957 | 3017 (54.4) | 5547 | 3.54E‐29 |
| Lower maternal educational levelb | 3577 (57.5) | 6220 | 4466 (71.8) | 6218 | 1.31E‐62 |
| Allergic diseases latent classese | |||||
| No Disease | 3175 (50.0) | 6345 | 1150 (49.8) | 2309 | (Reference) |
| Atopic March | 175 (2.8) | 59 (2.5) | 0.621 | ||
| Persistent eczema and wheeze | 181 (2.9) | 72 (3.1) | 0.508 | ||
| Persistent eczema with late‐onset rhinitis | 307 (4.8) | 111 (4.8) | 0.991 | ||
| Persistent wheeze with late‐onset rhinitis | 348 (5.5) | 149 (6.5) | 0.107 | ||
| Transient wheeze | 534 (8.4) | 195 (8.4) | 0.939 | ||
| Eczema only | 948 (15.0) | 323 (14.0) | 0.394 | ||
| Rhinitis only | 677 (10.7) | 250 (10.8) | 0.820 | ||
| MAAS | |||||
| Gender (male) | 482 (53.8) | 896 | 186 (55.7) | 287 | 0.305 |
| Lower combined social classa | 225 (36.9) | 610 | 60 (43.2) | 139 | 0.101 |
| Lower maternal educational levelb | 359 (55.3) | 649 | 45 (57.7) | 78 | 0.392 |
| Allergic diseases latent classese | |||||
| No Disease | 322 (35.9) | 896 | 87 (38.9) | 223 | (reference) |
| Atopic March | 55 (6.1) | 11 (5.1) | 0.471 | ||
| Persistent eczema and wheeze | 46 (5.1) | 10 (4.6) | 0.611 | ||
| Persistent eczema with late‐onset rhinitis | 73 (8.1) | 18 (7.9) | 0.710 | ||
| Persistent wheeze with late‐onset rhinitis | 81 (9.0) | 18 (8.2) | 0.557 | ||
| Transient wheeze | 65 (7.3) | 15 (6.8) | 0.644 | ||
| Eczema only | 141 (15.7) | 34 (15.3) | 0.634 | ||
| Rhinitis only | 114 (12.8) | 29 (13.1) | 0.836 | ||
a
Mother and partner level of occupation (manual vs non‐manual) in ALSPAC, combined socio‐economic status (not working, routine, intermediate vs managerial) in MAAS.
b
In ALSPAC, mother educated to the General Certificate of Education level (school‐leaving certificate) or lower; In MAAS, mother not educated to UK A or As level (data from follow‐up questionnaire at 13‐16 y).
c
P‐values are from chi‐squared test for binary variables and logistic regression for latent variables (baseline group is “no disease” class), comparing “included” vs “excluded” individuals.
d
Participants with SNP data and outcome data available.
e
Proportions were weighted by posterior membership probabilities.