Table 2.
ALSPAC‐MAAS pooled estimates of the associations between standardized genetic scores and profile latent classes before and after excluding SNPs rs61816761 (FLG) and rs921650 (GSDMB)
| Allergic diseases latent classes | ALSPAC‐MAAS pooled multinomial odds ratio (95% CI) | |
|---|---|---|
| Stand. Score | Stand. Score excluding FLG and GSDMB SNPs | |
| Atopic March | 1.99 (1.74,2.29) | 1.90 (1.66,2.18) |
| Persistent eczema and wheeze | 1.39 (1.22,1.60) | 1.35 (1.17,1.54) |
| Persistent eczema with late‐onset rhinitis | 1.51 (1.35,1.68) | 1.49 (1.34,1.66) |
| Persistent wheeze with late‐onset rhinitis | 1.44 (1.30,1.60) | 1.42 (1.28,1.57) |
| Transient wheeze | 1.11 (1.02,1.21) | 1.09 (1.00,1.19) |
| Eczema only | 1.16 (1.08,1.24) | 1.15 (1.07,1.23) |
| Rhinitis only | 1.21 (1.12,1.31) | 1.21 (1.12,1.31) |
| P‐value for differential associationa | 3.27E‐14 | 1.07E‐12 |
| P‐value for any associationb | 1.22E‐13 | 3.83E‐12 |
a
Overall test for heterogeneity between classes excluding the baseline class of “no disease”.
b
Overall test for heterogeneity between classes including the baseline class of “no disease” (Pooled multinomial Odds Ratio = 1).