Table 3.
ALSPAC‐MAAS pooled estimates of the associations between the top six nominal SNPs (heterogeneity p‐value excluding the baseline “no disease” class < 0.05) and allergic diseases latent classes
| SNP[RA] | ALSPAC‐MAAS pooled multinomial odds ratio (95% CI) | |||||
|---|---|---|---|---|---|---|
| rs61816761[A] | rs921650[A] | rs11652139[A] | rs479844[G] | rs6990534[A] | rs5743618[C] | |
| Nearby Gene | FLG | GSDMB | ||||
| Allergic diseases latent classes | ||||||
| Atopic March | 3.01 (1.79,5.08) | 1.36 (1.13,1.65) | 1.47 (1.20,1.80) | 1.12 (0.92,1.36) | 1.33 (1.09,1.62) | 1.31 (1.04,1.67) |
| Persistent eczema and wheeze | 1.87 (1.01,3.48) | 1.37 (1.13,1.66) | 1.22 (1.00,1.49) | 1.19 (0.98,1.44) | 0.92 (0.74,1.14) | 0.98 (0.78,1.22) |
| Persistent eczema with late‐onset rhinitis | 2.30 (1.45,3.65) | 0.95 (0.82,1.11) | 1.06 (0.91,1.24) | 1.21 (1.04,1.41) | 1.08 (0.91,1.27) | 1.06 (0.89, 1.26) |
| Persistent wheeze with late‐onset rhinitis | 0.87 (0.47,1.62) | 1.36 (1.18,1.57) | 1.22 (1.05,1.42) | 0.95 (0.82,1.10) | 1.03(0.88,1.21) | 1.13 (0.96,1.35) |
| Transient wheeze | 1.00 (0.60,1.66) | 1.24 (1.10,1.40) | 1.15 (1.02,1.31) | 1.02 (0.90,1.16) | 0.93 (0.81,1.07) | 0.97 (0.84, 1.13) |
| Eczema only | 1.63 (1.15,2.30) | 0.99 (0.90,1.09) | 0.98 (0.88,1.08) | 1.14 (1.03,1.26) | 0.96 (0.86,1.07) | 0.99 (0.89, 1.11) |
| Rhinitis only | 1.08 (0.69,1.68) | 1.00 (0.90,1.12) | 1.04 (0.93,1.17) | 0.95 (0.85,1.06) | 1.10 (0.98,1.24) | 1.19 (1.04, 1.36) |
| P‐value for differential associationa | 0.006 | 1.71E‐05 | 0.006 | 0.044 | 0.055 | 0.138 |
| P‐value for any associationb | 0.011 | 4.26E‐05 | 0.011 | 0.074 | 0.091 | 0.207 |
Abbreviation: RA, risk allele.
a
Overall test for heterogeneity between classes excluding the baseline class of “no disease”.
b
Overall test for heterogeneity between classes including the baseline class of “no disease” (Pooled multinomial Odds Ratio = 1).