Table 1.

The proportion of individual bile acids measured by HPLC‐MS/MS in women with ICP

BA (%)	Not on UDCA	On UDCA	Fold change in proportion	P‐value	95% CI
CA	51.4 (36.1–63.0)	18.7 (12.6–26.2)	0.42	<0.001	0.34–0.52
CDCA	24.9 (20.2–34.7)	13.2 (9.8–19.1)	0.55	<0.001	0.46–0.65
DCA	17.5 (4.0–26.4)	4.9 (1.9–10.1)	0.45	<0.001	0.34–0.60
LCA	0.5 (0.2–1.6)	0.8 (0.4–1.6)	1.40	0.059	0.99–1.99
UDCA	0.3 (0.0–0.9)	60.0 (42.8–69.0)	96.70	<0.001	64.18–145.72

BA, bile acid; CA, cholic acid; CDCA, chenodeoxycholic acid; CI, confidence interval; DCA, deoxycholic acid; LCA, lithocholic acid; UDCA, ursodeoxycholic acid.

Results shown as median (IQR). Values represent percentages of the total bile acid pool. Concentrations of individual BA species were measured by high‐performance liquid chromatography‐tandem mass spectrometry (HPLC‐MS/MS) and proportions calculated with reference to the sum of all individual BA concentrations. Both conjugated and unconjugated bile acid species were used for calculations.