Figure 2.

Clear cell chondrosarcoma areas with variable degrees of nuclear atypia. A, Clear cells are admixed with trabeculae of woven bone, resembling clear cell chondrosarcoma. Areas with large clear cells with distinct cytoplasmic membranes are encountered in most cases. Nuclei are small, regular, and without prominent atypia (case 1). B–D, Cells with slightly enlarged and hyperchromatic nuclei can be present (case 2, case 4, and case 5, respectively). Note the regular deposition of woven bone that is characteristic of clear cell chondrosarcoma. E, Severe atypia can be seen. Cells with enlarged, irregular and hyperchromatic nuclei are admixed with woven bone and osteoclast‐like giant cells (case 3). F, Occasionally, cells with bizarre and monstrous nuclei are distributed between more typical cells with round nuclei and prominent nucleoli, surrounded by abundant eosinophilic cytoplasm (case 3). Scale bar: 50 μm (A–E), 100 μm (F).