Figure 2.

Monocular deprivation leads to a robust shift in ocular dominance after long‐term treatment with fluoxetine (12 weeks). (a) Ocular dominance indexes of fluoxetine‐treated (IOSI 0.2 ± 0.03, IOSII −0.01 ± 0.03; n = 8) and Control groups (IOSI 0.19 ± 0.02, IOSII 0.19 ± 0.02; n = 5; one‐way ANOVA, Sidak‐corrected). (b–d) Representative optical imaging data: optical maps of cortical activity in the binocular part of the primary visual cortex, evoked by a drifting bar stimulus. The Control animals’ ipsilateral patch of activity is smaller, whereas in fluoxetine‐treated animals almost indistinguishable from contralateral patch. That shows the reduction in the response of the closed eye after monocular deprivation and corresponds to lower OD indexes in these animals. b: Control group; c and d: fluoxetine‐treated. Colour maps reflect relative retinotopy; black and white—magnitude of the optical signal. The grey scale below the magnitude maps: fractional change in reflection ×10⁴. The grey circle shows brain axes. Scale bar = 1 mm [Colour figure can be viewed at http://www.wileyonlinelibrary.com/]