Figure 4.

Ad.sDll4 impairs recovery of blood flux in NO‐Tie mice, even when paralleled by increased angiogenesis and arteriolargenesis. (A) Ad.sDll4 had no effect on recovery of blood flux after ischemia when compared to control mice but (B) a significant effect in the variation of recovery profiles was observed when this was added to NO‐Tie mice (3.22% of total variance, ***P = 0.0004). (C) Addition of Ad.sDll4 further worsened the outcome of NO‐Tie‐VEGF mice (1.80% of total variance, **P = 0.0070). Two‐way ANOVA with Sidak's post‐test: *P < 0.05, n = 12 mice/group. In all animal groups, addition of Ad.sDll4 led to an increase in both capillary (D‐F) and arteriole densities (G‐I). n = 5‐6 mice/group. Two‐tailed Mann‐Whitney test with 95% confidence interval: ****P < 0.0001