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. 2019 Oct 23;249(4):498–508. doi: 10.1002/path.5341

Figure 5.

PATH-5341-FIG-0005-c

ASPM‐iII selectively regulates cyclin E and cell cycle progression in PDAC cells. (A) IB showing the protein abundance level of cyclin E in NCKUH‐SP‐1 cells with control KD, ASPM‐vI KD or pan‐ASPM‐variant KD mediated by lentivirus‐mediated RNA interference. H2B was included as a loading control. (B) Cell cycle distributions of NCKUH‐SP‐1 cells with control KD or pan‐ASPM‐variant KD. (C) The percentage of cells in the different phases in the cell cycle or those with a sub‐G1 DNA content in NCKUH‐SP‐1 cells with control KD, ASPM‐vI KD or pan‐ASPM‐variant KD. NS, not significant. Mean ± SEM (n = 3 in each group). *p < 0.05; **p < 0.01; ***p < 0.001. (D) Line graphs showing the proliferative rate of NCKUH‐SP‐1 cells with control KD, ASPM‐vI KD or pan‐ASPM‐variant KD. Mean ± SEM (n = 3 in each group). **p < 0.01; ***p < 0.001 versus control KD.