Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Preparation and Hofmann degradation of amide 27 d. Reagents and conditions: (a) 1. 1.5 equiv Boc2O, 1.8 equiv pyridine, 1,4‐dioxane, 23 °C, 0.5 h; 2. 2.8 equiv (NH4)2CO3, 23 °C, 16 h; (b) 1.0 equiv PIDA, 2.5 equiv KOH, MeOH, CH2Cl2, 0 °C→23 °C, 16 h.
