Table 1.
Use of factor concentrates in severe VWD patients.
| Indication | Dose* (iu/kg) | Target levels of VWF:RCo and FVIII:C (iu/dl) | Treatment duration (days) | |
|---|---|---|---|---|
| Day 1 | After day 1 | |||
| Bleeding | ||||
| Mild to moderate | 20–40 | Peak >50–80 | Through >30 | 1–3 |
| Severe | 50 | Peak >100 | Through >50 | 3–10 |
| Intervention | ||||
| Dental extraction | 25 | Peak >50 | 1 | |
| Minor surgery | 30–60 | Peak >50–80 | Through >30 | 1–5 |
| Major surgery | 50–60 | Peak >100 | Through >50 | 7–10 |
| Delivery | 40–50 | Peak >100 | Through >50 | 3–7† |
*
The concentrate dose depends on the type and brand of concentrate.
†
Three to five days after vaginal labour, and 5–7 days after caesarean section, depending on bleeding and factor levels.