Figure 3.

Head circumference estimates for untreated individuals with severe MPS I, 0–36 months old. These panels show, for males (a) and females (b) with severe MPS I, the LMS estimated head circumference (red) and reference curves (blue) by age overlaid on MPS I registry data (gray scatter). (a): 195 males with 366 records; (b): 191 females with 362 observations. Median MPS I estimated head circumference is shown as solid red lines, and the 97th and 3rd percentiles are shown as red hatched lines. CDC median and 97th and 3rd percentiles curves are shown in blue. CDC, Centers for Disease Control and Prevention; MPS I, Mucopolysaccharidosis Type I; LMS, Lambda Mu Sigma