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. 2019 Jul 12;235(2):1759–1768. doi: 10.1002/jcp.29094

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© 2019 The Authors. Journal of Cellular Physiology Published by Wiley Periodicals, Inc.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Rapamycin suppresses PQ‐induced oxidant stress in pulmonary fibrosis. (a) The expression of ROS level was detected by DCFH‐DA assay. (b) RT‐qPCR was used to measure the expression of NQO1. (c–e) The levels of GSH and CAT, and SOD activity were evaluated by ELISA kit. (f) Western blot was applied to detect the expression of Nrf2, HO‐1, and Keap1 proteins. *p < .05, **p < .01, ***p < .001, compared with control group; ^# p < .05, ^## p < .01, ^### p < .001, compared with rapamycin group. CAT, catalase; DCFH‐DA, 2’,7’‐dichlorofluorescin diacetate; ELISA, enzyme‐linked immunosorbent assay; GSH, glutathione; Nrf2, nuclear factor E2‐related factor 2; PQ, paraquat; ROS, reactive oxygen species; RT‐qPCR, reverse transcriptase quantitative polymerase chain reaction; SOD, superoxide dismutase [Color figure can be viewed at wileyonlinelibrary.com]