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A model of how CCN5 may intervene fibrosis via transforming growth factor‐β (TGF‐β) pathway. Exogeneous TGF‐β1 induces fibroblast to myofibroblast transdifferentiation. Knock out (KO) of transforming growth factor‐β receptor 1 (TGFBR1), reduces the effect of TGF‐β1. Treatment of CCN5 decreases the transdifferentiation of fibroblast to myofibroblast by exogenous TGF‐β1. [Color figure can be viewed at wileyonlinelibrary.com]
