Figure 4.

Effects of CL316,243 on serum adipokines (adiponectin and fibroblast growth factor [FGF] 21) and renal expression of Fgf21 components in diabetic mice. A, Serum adiponectin and B, serum Fgf21 concentrations; C, Fgf21 protein and D, relative expression of β‐klotho (Klb) and FGF receptor 1c (Fgfr1c) mRNA in renal cortical tissues. Data are the mean ± SEM (n = 6 per group). *P < 0.05, **P < 0.01, ***P < 0.001 compared with control (non‐diabetic) mice; ^† P < 0.05, ^†† P < 0.01 compared with the diabetic control (DM‐Con) group. DM + CL, HFD combined with STZ‐induced diabetic mice treated with CL316,243