Figure 5.

Effects of CL316,243 on serum microRNAs (miR) and renal expression of target genes in diabetic mice. A, Relative expression of miR‐26a, miR‐30b, miR‐30c, miR‐99a, miR‐100 and miR‐181a extracted from the serum of non‐diabetic (Control), streptozotocin‐induced diabetic (DM‐Con), and CL316,243‐treated diabetic (DM + CL) mice. B, Relative mRNA expression of connective tissue growth factor (Ctgf), Snail1, Nox4, and early growth response factor 1 (Egr1) in renal cortical tissues. Data are the mean ± SEM (n = 6 per group). *P < 0.05, **P < 0.01, ***P < 0.001 compared with Control; ^† P < 0.05, ^†† P < 0.01 compared with the DM‐Con group