Table 2.

Biochemical and physical parameters of experimental animals at Week 12

Parameters	Control	DM + CL	DM‐Con
BW (g)	29.91 ± 0.97	30.51 ± 0.55	29.24 ± 0.70
KW (g)	0.20 ± 0.02	0.22 ± 0.01†	0.27 ± 0.02**
KW/BW (×10−3)	6.40 ± 0.42	6.94 ± 0.37††	9.03 ± 0.49**
RBG (mM)2	8.30 ± 0.46	20.58 ± 3.55*	23.6 ± 3.87**
Food intake (kcal/day per mouse)	11.82 ± 0.31	18.92 ± 0.80*** , ††	15.72 ± 0.50**
Serum Cr (μM)	22.79 ± 6.79	23.4 ± 5.43	24.65 ± 5.25
Urine volume (mL)	1.84 ± 0.22	2.77 ± 1.20†	11.50 ± 2.09*

Data are the mean ± SEM (n = 7–9 per group).

BW, body weight; Cr, creatinine; DM + CL, diabetic mice treated with CL316,243; KW, kidney weight; RBG, random blood glucose.

^* P < 0.05

^** P < 0.01

^*** P < 0.001 compared with the control (normal) group

^† P < 0.05;

^†† P < 0.01 compared with the diabetic control (DM‐Con) group.