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. 2019 Oct 17;86(6):866–877. doi: 10.1002/ana.25600

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© 2019 The Authors. Annals of Neurology published by Wiley Periodicals, Inc. on behalf of American Neurological Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

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Complex process of cognitive aging. Red curves show worse values for all predictors (low education/occupation, high amyloid burden, low genu fractional anisotropy [FA]), and blue curves show the better values for all predictors (high education/occupation, low amyloid burden, high genu FA). Plots are shown for males versus females as well as APOE4 carriers versus APOE4 noncarriers. SUVR = standardized uptake value ratio. [Correction added on 25 October 2019, after first online publication: There was an error in the table portion at the bottom of Figure 5. The age range in the 3rd column has been changed from 60‐60 to 60‐69.]