Table 2.

Total, Direct, and Indirect Effects Seen on Components of the Resilience, Vascular, and Amyloid Pathways (Shown in Fig 2)

Path	Total Effect		Direct Effect		Total Indirect Effect
	Estimate (SE)	p	Estimate (SE)	p	Estimate (SE)	p
Education/occupation, systemic vascular health, and genu FA as outcomes
Age [decade] → education/occupation	−0.306 (0.074)	<0.001	−0.306 (0.074)	<0.001	—	—
Male → education/occupation	0.910 (0.143)	<0.001	0.910 (0.143)	<0.001	—	—
Age [decade] → CMC	0.581 (0.040)	<0.001	0.564 (0.040)	<0.001	0.017 (0.006)	0.007
Male → CMC	0.391 (0.076)	<0.001	0.441 (0.077)	<0.001	−0.050 (0.016)	0.002
Education/occupation → CMC	−0.055 (0.015)	<0.001	−0.055 (0.015)	<0.001	—	—
Age [decade] → genu FA	−0.514 (0.028)	<0.001	−0.469 (0.030)	<0.001	−0.045 (0.012)	<0.001
Male → genu FA	0.227 (0.053)	<0.001	0.257 (0.053)	<0.001	−0.030 (0.010)	0.002
Education/occupation → genu FA	0.004 (0.002)	0.008	—	—	0.004 (0.002)	0.008
CMC → genu FA	−0.078 (0.020)	<0.001	−0.078 (0.020)	<0.001	—	—
Amyloid as an outcome
Age [decade] → log [amyloid]	0.443 (0.026)	<0.001	0.443 (0.026)	<0.001	—	—
Male → log [amyloid]	−0.100 (0.050)	0.045	−0.100 (0.050)	0.045	—	—
APOE4 → log [amyloid]	0.599 (0.055)	<0.001	0.599 (0.055)	<0.001	—	—

CMC = cardiovascular and metabolic conditions; FA = fractional anisotropy; SE = standard error.