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Summary of LSEC fenestrae structure and functionality changes due to various actin/spectrin active agents
| Active agent | Actin structure modification | Spectrin oxidation | Cell stiffness | Fenestrae open/closed | Porosity |
|---|---|---|---|---|---|
| CB | Depolymerization | No | Low | Largely open | Increased by 200% |
| DIA | Actin cross‐linking | Yes | High | Closed | Greatly reduced |
| IAA | Depolymerization | Yes | Low | Fast switching | Increased by 20%‐30% |
