Table 3.

Diagnostic performance of dd‐cfDNA(cp/mL) and dd‐cfDNA(%) at calculated thresholds attained by simultaneous maximization of sensitivity and specificity. When feasible, values are given with 95% confidence interval. Outliers in the Stable Phase patient group were excluded prior to analysis

	dd‐cfDNA(cp/mL)	dd‐cfDNA(%)
Threshold	52	0.43
Sensitivity	0.73 (0.55‐0.91)	0.73 (0.45‐0.86)
Specificity	0.73 (0.59‐0.88)	0.69 (0.37‐0.79)
PPV	0.13	0.12
NPV	0.98	0.98
DOR	7.31 (2.8‐19.2)	6.02 (2.4‐15.1)

Abbreviations: BPR, biopsy‐proven rejection; DOR, diagnostic odds ratio; NPV, negative predictive value; PPV, positive predictive value; ROC, receiver operating characteristic.

Obtained from ROC curves in BPR (N = 15; n = 22) vs Stable Phase patients samples (N = 82; n = 395).