Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Oct 10;25(64):14572–14582. doi: 10.1002/chem.201902814

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Scheme 1 — Attempted SPPS of (Thr2, Ser5) analogue 2. Reagents and conditions: (i) HOAt, PyAOP, DIPEA, DMF; (ii) HOAt, PyAOP, DIPEA, DMF, μwave 60 °C for 5 min; (iii) Fmoc deprotection (piperidine, DMF) followed by coupling (Fmoc‐Leu‐OH, HOAt, PyAOP, DIPEA, DMF)×2 (7 a) or coupling Fmoc‐(FmocHmb)Leu‐OH, HBTU, DIPEA, DMF)×2 (7 b); (iv) Fmoc deprotection (piperidine, DMF) followed by coupling (Fmoc‐Ser(tBu)‐OH, HOAt, PyAOP, DIPEA, DMF)×2; (v) Fmoc deprotection (piperidine, DMF) followed by coupling (Fmoc‐Ile‐OH, HOAt, PyAOP, DIPEA, DMF)×2; (vi) Teoc/TMSE deprotection (TBAF, DMF); (vii) Fmoc deprotection (piperidine, DMF).