Figure 2.

Cannabidiol (CBD) and clobazam combination therapy improved survival of Scn1a ^+/− mice. A, Spontaneous generalized tonic‐clonic seizure (GTCS) frequency of individual untreated and drug‐treated mice. Treatment began after the induction of a single hyperthermia‐induced seizure and spontaneous GTCS were subsequently quantified over a 60‐h recording period. Clobazam in both the absence and presence of CBD significantly reduced the proportion of mice experiencing GTCS (blue, open symbols), with n = 15‐19 per group (**P < 0.005, ****P < 0.0001; Fisher's exact test). B, Survival curves comparing untreated and drug‐treated mice. Clobazam in the presence of CBD significantly improved survival (blue line), with n = 15‐19 per group (**P < 0.005; log‐rank Mantel‐Cox)