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. 2019 Oct 17;58(48):17351–17358. doi: 10.1002/anie.201907901

Figure 1.

Figure 1

A) Schematic overview showing the NF‐Y trimer (NF‐YA: green, NF‐YB/C grey) bound to target DNA (blue). A potential inhibitor (orange) perturbs trimer assembly, thereby preventing NF‐Y from binding to DNA (structures based on PDB IDs: 4awl and 1nkp). B) Crystal structure (PDB ID: 6qmp, Table S2) of PBM (V267‐R295, green cartoon representation) in complex with the NF‐YB/C dimer (grey, surface representation). Selected PBM side chains are shown as ball‐and‐stick representation. For an overview of entire structure see Figure S2. C) The sequences of PBM (V267‐R295) and truncated peptides 1–6, along with their dissociation constants (K d) as determined by FP (errors account for 1σ, measurements performed in triplicate; for binding curves see Figure S5).