Table 3.
Platelet utilization outcomes by clinical indication. Wilcoxon rank‐sum test p values are shown in parentheses
| Mean values (median) | Heme/Oncology | Allogeneic HSCT | Autologous HSCT | Cardiovascular Surgery (CVS) | Other Med/Surgical | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Control | INTERCEPT | p value | Control | INTERCEPT | p value | Control | INTERCEPT | p value | Control | INTERCEPT | p value | Control | INTERCEPT | p value | |
| Patients | 355 | 441 | 277 | 411 | 110 | 130 | 414 | 748 | 880 | 1079 | |||||
| Platelets | 3,806 | 4,911 | 6,628 | 11,416 | 816 | 1,173 | 677 | 1,817 | 2,254 | 3,262 | |||||
| Mean plts/pt (median) | 10.7 (4.0) | 11.1 (4.0) | 0.763 | 23.9 (13.0) | 27.8 (18.0) | 0.111 (0.001) | 7.4 (3.5) | 9.0 (4.0) | 0.247 | 1.6 (1.0) | 2.4 (2.0) | <0.001 | 2.6 (1.0) | 3.0 (1.0) | 0.119 |
| Days of platelet support (median) | 16.9 (5.0) | 16.5 (5.0) | 0.842 | 31.7 (17.0) | 31.3 (20.0) | 0.880 (>0.05) | 11.4 (4.5) | 11.5 (5.0) | 0.980 | 1.4 (1.0) | 1.6 (1.0) | 0.011 | 2.9 (1.0) | 3.9 (1.0) | 0.179 |
| Number of cycles (median) | 2.8 (1.0) | 2.8 (1.0) | 0.895 | 2.7 (2.0) | 2.9 (2.0) | 0.340 | 2.3 (1.5) | 2.3 (1.5) | 0934 | 1.0 (1.0) | 1.1 (1.0) | 0.077 | 1.3 (1.0) | 1.4 (1.0) | 0.073 |
| Days with platelet transfusion (median) | 9.5 (3.0) | 9.4 (3.0) | 0.928 | 20.4 (12.0) | 21.8 (15.0) | 0.446 | 6.9 (3.0) | 7.9 (4.0) | 0.38 1 | 1.3 (1.0) | 1.4 (1.0) | 0.003 | 2.2 (1.0) | 2.5 (1.0) | 0.184 |
| Any RBCs transfused | 84.2% | 85.7% | 0.617 | 94.9% | 94.9% | 1.000 | 73.6% | 70.8% | 0.666 | 92.0% | 82.2% | <0.001 | 35.6% | 41.3% | 0.010 |
| Number of RBCs (median) | 12.6 (6.0) | 11.2 (6.0) | 0.245 | 18.7 (10.0) | 19.3 (13.0) | 0.721 | 7.5 (2.0) | 7.0 (2.0) | 0.774 | 9.7 (6.0) | 8.5 (4.0) | 0.136 | 3.5 (0.0) | 4.1 (0.0) | 0.151 |
| Count before transfusion (×109/L) (median) | 17.4 (15.0) | 14.7 (12.0) | <0.001 | 18.7 (16.0) | 14.2 (13.0) | <0.001 | 16.5 (15.0) | 13.4 (13.0) | <0.001 | 90.7 (67.0) | 81.0 (69.0) | 0.176 | 40.5 (18.0) | 27.8 (13.0) | <0.001 |
| Interval (median) | 1.9 (1.9) | 1.7 (1.6) | 0.048 | 1.5 (1.4) | 1.3 (1.2) | <0.001 | 1.8 (1.6) | 1.3 (1.0) | <0.001 | 0.5 (0.0) | 0.4 (0.0) | 0.220 | 1.2 (1.0) | 1.0 (0.9) | 0.106 |
| CI (×109/L) (median) | 17.6 (15.0) | 15.7 (13.0) | <0.001 | 19.2 (16.0) | 13.4 (11.0) | <0.001 | 20.3 (17.0) | 12.5 (11.0) | <0.001 | 22.8 (22.0) | 22.3 (20.0) | 0.876 | 18.1 (14.0) | 14.2 (10.0) | 0.004 |
| Proportion of PCs with CCI data | 52.8% | 63.2% | 64.4% | 78.1% | 52.2% | 70.7% | 11.8% | 11.1% | 13.8% | 33.5% | |||||
| CCI (×103) (median) | 9.8 (9.1) | 8.7 (7.5) | <0.001 | 11.1 (9.8) | 8.0 (6.8) | <0.001 | 10.4 (9.5) | 7.2 (6.6) | <0.001 | 13.8 (12.7) | 13.5 (12.7) | 0.910 | 10.1 (7.7) | 7.6 (6.0) | 0.002 |
| CCI ≥ 5.0 × 103 | 74.1% | 68.9% | <0.001 | 77.6% | 63.8% | <0.001 | 77.5% | 62.2% | <0.001 | 70.0% | 75.2% | 0.371 | 61.6% | 58.2% | 0.295 |
CCI = corrected count increment; CI = count increment; PC = platelet concentrate.