Table 1.
Transfusion ratio | Blood product exposure (units) | Pooled mean difference | 95% CI | p (overall effect) | I2 |
---|---|---|---|---|---|
RCTs | |||||
FFP:PLTs:RBCs 1:1:1 vs. <1:1:1 | RBCs | –0.65 | –1.75 to 0.45 | 0.25 | 0% |
FFP:PLTs:RBCs 1:1:1 vs. <1:1:1 | FFP | 1.91 | 0.92 to 2.90 | 0.0002 | 0% |
FFP:PLTs:RBCs 1:1:1 vs. <1:1:1 | PLTs | 3.28 | –2.66 to 9.23 | 0.28 | 87% |
Observational cohort studies | |||||
FFP:RBCs 1:1 vs. <1:1 | RBCs | –0.68 | –2.68 to 1.33 | 0.51 | 59% |
FFP:RBCs 1:1 vs. <1:1 | FFP | 8.88 | 3.76 to 14.0 | 0.0007 | 95% |
FFP:RBCs 1:1 vs. <1:1 | PLTs | 0.80 | –0.75 to 2.36 | 0.31 | 84% |
FFP:RBCs 1:1.5 vs. <1:1.5 | RBCs | –0.26 | –6.28 to 5.76 | 0.93 | 98% |
FFP:RBCs 1:1.5 vs. <1:1.5 | FFP | 9.65 | 5.35 to 13.95 | < 0.0001 | 98% |
FFP:RBCs 1:1.5 vs. <1:1.5 | PLTs | 1.04 | –0.48 to 2.55 | 0.18 | 88% |
FFP:RBCs 1:2 vs. <1:2 | RBCs | –1.12 | –4.27 to 2.03 | 0.48 | 91% |
FFP:RBCs 1:2 vs. <1:2 | FFP | 9.24 | 3.95 to 14.53 | 0.0006 | 98% |
FFP:RBCs 1:2 vs. <1:2 | PLTs | 7.82 | –2.83 to 18.47 | 0.15 | 98% |
PLTs:RBCs 1:1 vs. <1:1 | RBCs | –0.39 | –5.121 to 4.32 | 0.87 | 86% |