Table 1.

Facts from JEB gene replacement therapies

Genetically corrected epidermal grafts LAMB3 Showed regeneration of morphologically normal, fully differentiated and functional, mechanically stable and non‐blistering transgenic skin Can replace up to 80% of a patient's diseased skin84 Showed sustained synthesis of the transgenic protein131 Harbour EpSCs which expanded and ensured long‐term or permanent regeneration84 Despite the risk of insertional mutagenesis tumorigenicity has not been observed within a follow‐up period of currently more than 12 y (83, 84, 131, and unpublished observations) Following regeneration, there was no evidence of an immune response against the newly expressed protein (unpublished observations)