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. 2019 Sep 20;78(12):1712–1721. doi: 10.1136/annrheumdis-2019-216059

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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Corresponding increase of memory Tregs and CD45RA⁻TNFα⁺ prior to relapse. Supervised gating of Tregs and CD45RA⁻Tregs in patients with JIA (A) prior (n=20) and (B) after withdrawal (n=16) of therapy. (C–D) Tregs cells from patients with JIA (n=20; relapse=9, remission=11) prior to withdrawal were analysed with t-SNE and (C) segregated into four nodes, with node 3 (p<0.05) enriched in relapse individuals. (D) Phenotype of node 3 is depicted (red-dotted box and arrowhead). (E) Correlation analysis of frequency of Tregs or CD45RA⁻Tregs with CD45RA⁻TNFα⁺. Comparison of cellular subsets performed with Mann-Whitney U, two-tailed test, means±SD. *p<0.05, ****p<0.0001. Correlation analysis performed with Pearson correlation, two-tailed test. ns, not significant; TNFα, tumour necrosis factor alpha; t-SNE, t-distributed stochastic neighbour embedding.