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. 2019 Oct 2;78(12):1642–1652. doi: 10.1136/annrheumdis-2019-215751

Figure 2.

Figure 2

Patient demographics and disease activity: comparison between pathotypes. (A) Number of biopsy procedures per joint. MCP, metacarpophalangeal; MTP, metatarsophalangeal; PIP, proximal interphalangeal. (B) Representative images of synovial pathotypes. Sections underwent immunohistochemical staining and semiquantitative scoring (0–4) to determine the degree of CD20 +B cells, CD3 +T cells, CD68 +lining) and sublining macrophage and CD138 +plasma cell infiltration. Sections were categorised into three pathotypes: (1) pauci-immune (CD68 SL <2 and or CD3, CD20, CD138 <1), (2) diffuse myeloid: (CD68SL >2, CD20 <1 and or CD3 >1) and (3) lymphomyeloid: (grade 2–3 CD20 +aggregates, CD20 >2). Arrow heads indicate positive stain cells. Empty arrows indicate B cell aggregates. (C) Demographic analysis by pathotype. Data are presented as mean and SD for numerical variables and frequency and percentage for categorical variables. Baseline characteristics between the three pathotypes were compared using a Kruskall-Wallis test and Fisher test (RF and ACPA positivity) as appropriate. Post hoc analysis for significant differences using the Dunn test for multiple comparison. A p value of <0.05 was considered statistically significant. (D) Pathotype according to disease duration (months) at diagnosis. Absolute values (N) and percentage. A p value of <0.05 was considered statistically significant. ACPA titre, anticitrullinated protein antibody titre (IU/L); ACPA +ve, anticitrullinated protein antibody (>20 IU/L); CRP, C reactive protein; DAS28, Disease Activity Score 28 joints; ESR, erythrocyte sedimentation rate; RF titre, rheumatoid factor titre (IU/mL); RF +ve, rheumatoid factor serum positive (>15 IU/L); 28TJC, 28 tender joint count; 28SJC, 28 swollen joint count.