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. Author manuscript; available in PMC: 2020 May 25.
Published in final edited form as: Nat Struct Mol Biol. 2019 Nov 25;26(12):1132–1140. doi: 10.1038/s41594-019-0331-x

Extended Data Fig. 6. Guanosine interrupts the intrinsic helical propensity of poly(A).

Extended Data Fig. 6

Circular dichroism (CD) spectra of AAAAAA (red), AAGAAG (blue) and AAGGAA (green) RNA oligonucleotides are plotted. These spectra are averaged from 9 independent measurements performed on the same samples. The AAAAAA oligo displays a CD signature characteristic for the helical conformation of poly(A), as described previously 52. Introduction of guanosines significantly disrupts this helical structure.