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. Author manuscript; available in PMC: 2020 May 25.
Published in final edited form as: Nat Struct Mol Biol. 2019 Nov 25;26(12):1132–1140. doi: 10.1038/s41594-019-0331-x

Fig. 7. Coincidence detection model for ribosome stalling on poly(A).

Fig. 7

Translation of the first few AAA codons progressively slows elongation due to lysine interactions within the exit tunnel favoring a peptidyl-tRNA geometry that is suboptimal for peptide bond formation. In the context of slow peptide bond formation, the decoding center has greater opportunities for rearrangement, which further slows elongation and can cause the ribosome to stall. PTC and DC refer to peptidyl-transferase center and decoding center, respectively.