Figure 1.

Histology of renal biopsy specimen of patient 4 reveals tubular atrophy consistent with the most common renal phenotype related to RMND1. (a) A PAS stain image showing areas of tubular atrophy with no significant glomerular disease. Note thyroidization of some of the tubules and the interstitial widening (PAS, 20×). (b) A Masson trichrome stain showing interstitial fibrosis and separation of tubules with some interstitial inflammation. (Masson 10×). (c) An electron micrograph showing a low magnification view of tubular epithelial cell with abundant mitochondria (9,080×). (d) A higher magnification image showing some variability in size and shape of mitochondria but no significant inclusions or pathologic changes. (23,700×)