Table 2.
Predictive performance of miR‐130b, miR‐21, AFP, and their combination detection significance on HCC diagnosis
| Statistical parameters | miR‐130b | miR‐21 | AFP | miR‐130b + miR‐21 | miR‐130b + miR‐21 + AFP |
|---|---|---|---|---|---|
| Sensitivity (%) | 82.20 | 81.29 | 56.52 | 92.16 | 96.52 |
| Specificity (%) | 73.72 | 75.74 | 90.12 | 77.51 | 94.11 |
| Accuracy (%) | 81.27 | 85.92 | 77.18 | 88.91 | 93.42 |
| PPV (%) | 87.29 | 83.81 | 82.20 | 89.13 | 91.21 |
| NPV (%) | 78.52 | 82.56 | 67.52 | 85.30 | 89.91 |
| LR+ | 4.22 | 4.32 | 6.35 | 4.51 | 9.83 |
| LR− | 0.17 | 0.09 | 0.55 | 0.03 | 0.02 |
Combined miR‐130b and miR‐21 gave a better performance than individual miRNAs; combined miR‐130b, miR‐21, and AFP can give the best performance of all. It may provide a better view for HCC screening.
Abbreviations: AFP, alpha‐fetoprotein; LR+, positive likelihood ratio; LR−, negative likelihood ratio; miRNAs, microRNAs; NPV, negative predictive value; PPV, positive predictive value.