. 2019 Oct 30;7(12):e1020. doi: 10.1002/mgg3.1020

Table 2.

Meta‐analysis of the association between MTHFR C677T polymorphism and T2DM susceptibility

Variables	No. of studies	Homozygous		Heterozygous		Recessive		Dominant		Allele
		TT versus CC		CT versus CC		TT versus CT/CC		CT/TT versus CC		T versus C
		OR (95% CI)	p^het	OR (95% CI)	p^het	OR (95% CI)	p^het	OR (95% CI)	p^het	OR (95% CI)	p^het
All	68	1.64 (1.39–1.94)	<.001	1.38 (1.20–1.59)	<.001	1.41 (1.23–1.61)	<0.001	1.47 (1.27–1.70)	<.001	1.37 (1.23–1.52)	<.001
Ethnicity
Asian	52	1.78 (1.48–2.15)	<.001	1.51 (1.33–1.70)	<.001	1.43 (1.23–1.67)	<0.001	1.60 (1.40–1.82)	<.001	1.44 (1.29–1.59)	<.001
Caucasian	11	1.20 (0.81–1.79)	.007	0.79 (0.52–1.21)	<.001	1.43 (1.14–1.79)	0.457	0.87 (0.57–1.32)	<.001	0.97 (0.72–1.32)	<.001
African	5	1.70 (0.63–4.57)	<.001	1.88(0.75–4.74)	<.001	1.45 (0.62–3.39)	0.002	2.15 (0.86–5.42)	<.001	1.92 (0.98–3.73)	<.001
HWE
>0.05	52	1.76 (1.45–2.13)	<.001	1.34 (1.14–1.57)	<.001	1.50 (1.29–1.75)	0.006	1.48 (1.26–1.73)	<.001	1.39 (1.24–1.56)	<.001
≤0.05	16	1.38 (0.99–1.92)	<.001	1.48 (1.11–1.99)	<.001	1.19 (0.92–1.55)	<0.001	1.44 (1.07–1.95)	<.001	1.29 (1.01–1.65)	<.001
Quality score
>9	20	1.46 (1.12–1.89)	<.001	1.29 (0.99–1.69)	<.001	1.37 (1.12–1.68)	0.003	1.36 (1.05–1.75)	<.001	1.30 (1.09–1.56)	<.001
≤9	48	1.78 (1.43–2.23)	<.001	1.42 (1.21–1.67)	<.001	1.45 (1.21–1.73)	0.001	1.53 (1.29–1.82)	<.001	1.40 (1.23–1.60)	<.001

The GenBank reference sequence and version number for the gene is: MTHFR (NM_005957.5). Values were in bold if 95% CIs excluded 1 or p values less than .05.

Abbreviations: CI, confidence interval; Het, heterogeneity; HWE, Hardy–Weinberg equilibrium; OR, odds ratio; T2DM, type 2 diabetes mellitus.