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. 2019 Oct 23;7(12):e1014. doi: 10.1002/mgg3.1014

Table 1.

Genotype, allele, and haplotype frequencies of CD40 SNPs (−1 C > T and 6,048 G > T) in CS and SLE patients

SNP CS n = 294 (%) SLE n = 293 (%) p value OR (CI 95%) p value
−1 C > T (rs1883832)  
CC 193 (65.5) 169 (57.7) .027 1
CT 95 (32.3) 107 (36.5) 1.286 [0.911–1.816] .152
TT 6 (2) 17 (5.8) 3.236 [1.247–8.397] .016
Allele  
C 481 (81.8) 445 (75.9) .014 1
T 107 (18.2) 141 (24.1) 1.424 [1.074–1.889] .014
Dominant  
CC 193 (65.6) 169 (57.7) .047 1
CT + TT 101 (34.4) 124 (42.3) 1.402 [1.004–1.958] .047
6,048 G > T (rs4810485)  
GG 192 (65.3) 162 (55.3) .03 1
GT 94 (32) 116 (39.6) 1.463 [1.038–2.061] .029
TT 8 (2.7) 15 (5.1) 2.222 [0.918–5.376] .085
Allele  
G 478 (81.3) 440 (75.1) .010 1
T 110 (18.7) 146 (24.9) 1.442 [1.090–1.907] .010
Dominant  
GG 192 (65.3) 162 (553) .013 1
GT + TT 102 (34.7) 131 (44.7) 1.522 [1.091–2.123] .013
Haplotype* 2n = 588 (%) 2n = 586 (%)  
C G 475 (80.7) 435 (74.2) 1
T T 104 (17.7) 136 (23.2) 1.428 [1.072–1.902] .014

Abbreviations: CI, Confidence interval; CS, control subjects; OR, odds ratio; SLE, systemic lupus erythematosus; SNP, single nucleotide polymorphism.

*

Haplotype analysis included the −1 C > T (rs1883832) and 6048G > T (rs4810485) polymorphisms of CD40 gene and all those with a frequency <0.03 were ignored in the analysis.