Table 4.

Alternative transcriptional regulation

Alternative Transcription Regulator	Protein details		Methods used to Identify Putative Transcriptional Regulator	PubMed ID
LactoferrinHSF1	TRFL_HUMAN DeltaLfHSF1_HUMAN	CLN3 harbors an HSF 1 site I at a proximal Alu in an antisense orientation	One form of LF is secreted in body fluids (sLF) whereas an alternative form deltal LF, regulated by a different promoter, is present in normal tissues. Delta LF is downregulated in breast cancer. The CLN3 promoter is downregulated in delta LF expressing HEK cell upon heat shock in microarray experiments.	Kim, Kang, and Kim (2013) and Pandey et al. (2011)
MITFLactoferrin	MITF_HUMANTRFL_HUMAN DeltaLf	MITF interacts with the putative CLN3 promoter	Putative CLN3 promoters have been pulled down by gene‐wide chromatin immunoprecipitation of MITF. One form of LF is secreted in body fluids (sLF) whereas an alternative form deltal LF, regulated by a different promoter, is present in normal tissues. Delta LF is downregulated in breast cancer. CLN3 is downregulated in delta LF expressing cell's.promoter.	Bertolotto et al. (2011) and Kim et al. (2013)
N‐MyristoylationN‐Myc	N‐myristoyltransferase_(HUMAN)MYCN_MOUSE	N‐Myc regulates transcription of CLN3	Using SILAC, researchers found that CLN3 is N‐myristoylated. The authors studied changes in gene expression in embryonic stem cells after the induction of various transcription factors. CLN3 was included in the analyses.	Chen et al. (2008) and Nishiyama et al. (2009)